Aminocaproic Acid and tranxamic acid
(Antifibrinolytic Drugs )
الاول هو ما يدور حديثنا عنه لكن الثاني موجود في BNF
Some commonly used brand names are
In the U.S
Amicar 1
Cyklokapron 2
In Canada
Another commonly used name for aminocaproic acid is epsilon-aminocaproic acid
This information applies to the following medicines
i 1- Aminocaproic Acid (a-mee-noe-ka-PROE-ik ASS-id) i
i 2-TranexamicAcid (tran-ex-AM-ikASS-id)i
Category
Description
Antifibrinolytic (an-tee-fye-bri-noh-LIT-ik) agents are used to treat serious bleeding, especially when the bleeding occurs after dental surgery (particularly in patients with hemophilia) or certain other kinds of surgery. These medicines are also sometimes given before an operation to prevent serious bleeding in patients with medical problems that increase the chance of serious bleeding
Antifibrinolytic agents may also be used for other conditions as determined by your doctor
Antifibrinolytic agents are available only with your doctor's prescription, in the following dosage forms
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Aminocaproic acid
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Tranexamic acid
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Parenteral
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Aminocaproic acid
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Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For antifibrinolytic agents, the following should be considered
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to aminocaproic acid or tranexamic acid. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes
Pregnancy—Studies on birth defects have not been done in humans. However, these medicines have been given to pregnant women without causing birth defects or other problems
Studies on effects of aminocaproic acid in pregnancy have not been done in animals. Tranexamic acid has not been shown to cause birth defects or other problems in animal studies
Breast-feeding—These medicines have not been reported to cause problems in nursing babies. However, small amounts of tranexamic acid pass into the breast milk
Children—Although there is no specific information comparing use of aminocaproic acid or tranexamic acid in children with use in other age groups, these medicines are not expected to cause different side effects or problems in children than they do in adults
Older adults
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For aminocaproic acid : Although there is no specific information comparing use of aminocaproic acid in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults
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For tranexamic acid : Tranexamic acid has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine
Other medical problems—The presence of other medical problems may affect the use of antifibrinolytic agents. Make sure you tell your doctor if you have any other medical problems, especially
Proper Use of This Medicine
Take this medicine only as directed by your doctor . Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects
Dosing—The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so
Children—Dose is based on body weight or size and must be determined by your doctor. At first, the dose is usually 100 mg per kg (45.4 mg per pound) of body weight, injected into a vein over a period of one hour. Then the dose is 33.3 mg per kg (15.1 mg per pound) of body weight per hour, injected into a vein
Missed dose—
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For aminocaproic acid (e.g., Amicar): If you miss a dose, take it as soon as possible. However, if you do not remember until it is almost time for your next dose, double the next dose. Then go back to your regular dosing schedule
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For tranexamic acid (e.g., Cyklokapron): If you miss a dose, take it as soon as possible. Then take any remaining doses for the day at regularly spaced times. Do not double doses. If you have any questions about this, check with your doctor
Storage—To store this medicine
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Keep out of the reach of children
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Store away from heat and direct light
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Do not store the tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down
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Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children
Precautions While Using This Medicine
If you will be taking tranexamic acid for longer than several days, your doctor may want you to have your eyes checked regularly by an ophthalmologist (eye doctor). This will allow your doctor to check for unwanted effects that may be caused by this medicine
If you are using aminocaproic acid syrup as a mouth rinse to control oral bleeding, and you are in the first or second trimester of pregnancy, you should spit out the syrup after rinsing without swallowing it
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome
Diarrhea; dry ejaculation; nausea or vomiting; unusual menstrual discomfort; watery eyes
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor
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